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[艾叶对人胃癌细胞SGC - 7901的形态学变化及抑制作用]

[Morphological changes and inhibiting effect on human gastric cancer cell SGC-7901 caused by aining].

作者信息

Su Miancheng, Dai Mei, Lü Xiaoying, Li Hongkun, Liu Jilin

机构信息

National Engineering Research Center for Mordernization of TCM, Zhuhai 519020.

出版信息

Zhong Yao Cai. 2002 May;25(5):339-42.

Abstract

OBJECTIVE

To investigate the inhibiting effect of Aining on the human gastric cancer cells.

METHODS

Morphological and MTT methods were adopted to explore the inhibiting effect of Aining and cisplatin (DDP) on the proliferation of SGC-7901 cancer cell.

RESULTS

Apoptotic morphological changes were seen after the cells cultured with Aining and DDP; inhibiting rate of 1 g/L Aining group was 51%, which had no significant differences with the inhibiting rate 53% of the 25 mg/L DDP group. But both the Aining and the DDP groups were significantly different from the blank group (P < 0.01).

CONCLUSION

Not only DDP but also Aining could inhibit the proliferation activity of the human gastric cancer cells, and the traditional Chinese medicine compound prescription Aining is very likely to become a new medicine which is utilized to inhibit cancer.

摘要

目的

探讨艾宁对人胃癌细胞的抑制作用。

方法

采用形态学和MTT法,研究艾宁和顺铂(DDP)对SGC - 7901癌细胞增殖的抑制作用。

结果

用艾宁和DDP培养细胞后可见凋亡形态学改变;1 g/L艾宁组的抑制率为51%,与25 mg/L DDP组53%的抑制率无显著差异。但艾宁组和DDP组与空白组均有显著差异(P < 0.01)。

结论

DDP和艾宁均可抑制人胃癌细胞的增殖活性,中药复方制剂艾宁很有可能成为一种新的抗癌药物。

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