Institute of Traditional Uighur Medicine of Xinjiang, Urumqi 830001.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 Feb;22(2):126-8.
To explore the protective effect of Artemisia rupestris extract (ARE) on chemical liver injury and immunological hepatitis.
Mice model of immunological hepatitis was established by lipopolysaccharide plus Bacillus Calmette-Guérin vaccine (BCG), and the models of liver injury was induced by D-galactosamine or carbon tetrachloride (CCl4) in mice and rats. The effects of ARE in preventing and treating immunological hepatitis and protecting liver injury were observed.
ARE significantly lowered the serum alanine transaminase (ALT) in immunological hepatitis (P < 0.05), CCl4 induced liver injury model mice and rats (P < 0.01), and in D-galactosamine induced liver injury mice (P < 0.05).
ARE has significantly protective effect against chemical liver injury and could treat immunological hepatitis, but with no effect in preventing immunological hepatitis. These might be the partial pharmacologic basis for using ARE in treating hepatitis.
探讨岩艾提取物（ARE）对化学性肝损伤及免疫性肝炎的保护作用。
采用脂多糖加卡介苗（BCG）建立免疫性肝炎小鼠模型，用D - 半乳糖胺或四氯化碳（CCl4）诱导小鼠和大鼠肝损伤模型。观察ARE预防和治疗免疫性肝炎及保护肝损伤的作用。
ARE能显著降低免疫性肝炎小鼠（P < 0.05）、CCl4诱导的肝损伤模型小鼠和大鼠（P < 0.01）以及D - 半乳糖胺诱导的肝损伤小鼠血清丙氨酸转氨酶（ALT）水平（P < 0.05）。
ARE对化学性肝损伤有显著保护作用，可治疗免疫性肝炎，但对预防免疫性肝炎无效。这些可能是ARE用于治疗肝炎的部分药理学基础。
