Laboratory of Molecular Bases of Ageing, Nencki Institute of Experimental Biology, PAS, Warsaw, Poland.
Immun Ageing. 2010 Jan 17;7(1):1. doi: 10.1186/1742-4933-7-1.
A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy between April 7 and 8th 2009. Here the lecture by Sikora with some input from the chairpersons Scapagnini and Barbagallo is summarized. Ageing is manifested by the decreasing health status and increasing probability to acquire age-related disease such as cancer, Alzheimer's disease, atherosclerosis, metabolic disorders and others. They are likely caused by low grade inflammation driven by oxygen stress and manifested by the increased level of pro-inflammatory cytokines such as IL-1, IL-6 and TNF-alpha, encoded by genes activated by the transcription factor NF-kappaB. It is believed that ageing is plastic and can be slowed down by caloric restriction as well as by some nutraceuticals. Accordingly, slowing down ageing and postponing the onset of age-related diseases might be achieved by blocking the NF-kappaB-dependent inflammation. In this review we consider the possibility of the spice curcumin, a powerful antioxidant and anti-inflammatory agent possibly capable of improving the health status of the elderly.
一个关于成功和不成功衰老的病理生理学的研讨会于 2009 年 4 月 7 日至 8 日在意大利巴勒莫举行。这里总结了 Sikora 的演讲和主席 Scapagnini 和 Barbagallo 的一些补充。衰老是由健康状况下降和获得与年龄相关的疾病（如癌症、老年痴呆症、动脉粥样硬化、代谢紊乱等）的可能性增加所表现出来的。这些疾病可能是由氧应激驱动的低度炎症引起的，表现为促炎细胞因子（如 IL-1、IL-6 和 TNF-α）水平升高，这些细胞因子的基因被转录因子 NF-κB 激活。人们相信衰老是可塑的，可以通过限制热量以及一些营养保健品来减缓。因此，通过阻断 NF-κB 依赖性炎症，可能可以减缓衰老并推迟与年龄相关的疾病的发生。在这篇综述中，我们考虑了香料姜黄素的可能性，姜黄素是一种强大的抗氧化剂和抗炎剂，可能能够改善老年人的健康状况。
