Pertschuk L P, Woda B A, Vuletin J C, Brigati D J, Soriano C B, Nicastri A D
Am J Clin Pathol. 1976 Mar;65(3):301-7. doi: 10.1093/ajcp/65.3.301.
Staphylococcus aureus antigen was identified within the glomeruli of a patient with acute bacterial endocarditis and diffuse glomerulonephritis. Routine immunofluorescence had revealed only granular deposits of complement (C3). C3 activator and C4 were not present. Direct immunofluorescence studies with a specific anti-Staphylococcus aureus conjugate were positive. Electron microscopy showed subepithelial and intramembranous electron-dense deposits. Eluates of the kidney did not contain anti-S. aureus antibody. The absence of immunoglobin suggests that the toxic action of S. aureus antigens may activate complement and cause glomerular injury and that immune complexes are not essential for the production of glomerulonephritis in this entity.
在一名患有急性细菌性心内膜炎和弥漫性肾小球肾炎的患者肾小球内鉴定出金黄色葡萄球菌抗原。常规免疫荧光仅显示补体（C3）的颗粒状沉积。不存在C3激活剂和C4。用特异性抗金黄色葡萄球菌结合物进行的直接免疫荧光研究呈阳性。电子显微镜显示上皮下和膜内电子致密沉积物。肾脏洗脱液中不含抗金黄色葡萄球菌抗体。免疫球蛋白的缺乏表明金黄色葡萄球菌抗原的毒性作用可能激活补体并导致肾小球损伤，并且免疫复合物对于该实体中肾小球肾炎的发生并非必不可少。
