复发性前列腺基质肉瘤伴大量高级别前列腺上皮内瘤变。
Recurrent prostatic stromal sarcoma with massive high-grade prostatic intraepithelial neoplasia.
作者信息
Morikawa Teppei, Goto Akiteru, Tomita Kyoichi, Tsurumaki Yuzuri, Ota Satoshi, Kitamura Tadaichi, Fukayama Masashi
机构信息
Department of Human Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
出版信息
J Clin Pathol. 2007 Mar;60(3):330-2. doi: 10.1136/jcp.2006.039032.
A unique case of prostatic stromal sarcoma (PSS) that recurred in the pelvic cavity with massive high-grade prostatic intraepithelial neoplasia is described. A 52-year-old man who presented with urinary retention underwent a radical cystoprostatectomy. Tumour tissues of the prostate showed an admixture of hyperplastic glands and markedly cellular stroma of spindle cells arranged in a fascicular pattern, and the tumour was diagnosed as PSS. 66 months after the operation, CT scans revealed three recurrent tumours around the bilateral obturator and left fore iliopsoas. The recurrent tumours were biphasic neoplasms, as before, but the epithelial component had grown prominent and manifested overt atypia in a manner resembling high-grade prostatic intraepithelial neoplasia. Our findings suggest that not only the stromal component but also and the epithelial components of PSS may have malignant potential.
本文描述了一例独特的前列腺间质肉瘤（PSS），该病例在盆腔复发，并伴有大量高级别前列腺上皮内瘤变。一名因尿潴留就诊的52岁男性接受了根治性膀胱前列腺切除术。前列腺肿瘤组织显示增生性腺体与呈束状排列的明显细胞性梭形细胞间质混合存在，该肿瘤被诊断为PSS。术后66个月，CT扫描显示双侧闭孔和左髂腰肌前方有三处复发肿瘤。复发肿瘤与之前一样为双相性肿瘤，但上皮成分显著生长，并表现出明显异型性，类似于高级别前列腺上皮内瘤变。我们的研究结果表明，PSS不仅间质成分，而且上皮成分可能都具有恶性潜能。
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