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最早的细胞膜。

The first cell membranes.

作者信息

Deamer David, Dworkin Jason P, Sandford Scott A, Bernstein Max P, Allamandola Louis J

机构信息

Department of Chemistry and Biochemistry, University of California at Santa Cruz, Santa Cruz, California 95064, USA.

出版信息

Astrobiology. 2002 Winter;2(4):371-81. doi: 10.1089/153110702762470482.

Abstract

Organic compounds are synthesized in the interstellar medium and can be delivered to planetary surfaces such as the early Earth, where they mix with endogenous species. Some of these compounds are amphiphilic, having polar and nonpolar groups on the same molecule. Amphiphilic compounds spontaneously self-assemble into more complex structures such as bimolecular layers, which in turn form closed membranous vesicles. The first forms of cellular life required self-assembled membranes that were likely to have been produced from amphiphilic compounds on the prebiotic Earth. Laboratory simulations show that such vesicles readily encapsulate functional macromolecules, including nucleic acids and polymerases. The goal of future investigations will be to fabricate artificial cells as models of the origin of life.

摘要

有机化合物在星际介质中合成,并可被输送到行星表面,如早期的地球,在那里它们与内源性物质混合。其中一些化合物是两亲性的,在同一分子上具有极性和非极性基团。两亲性化合物会自发地自组装成更复杂的结构,如双分子层,进而形成封闭的膜状囊泡。细胞生命的最初形式需要自组装膜,而这些膜很可能是由前生物地球上的两亲性化合物产生的。实验室模拟表明,这种囊泡很容易包裹功能大分子,包括核酸和聚合酶。未来研究的目标将是制造人工细胞作为生命起源的模型。

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