Manhart Lisa E, Critchlow Cathy W, Holmes King K, Dutro Susan M, Eschenbach David A, Stevens Claire E, Totten Patricia A
Department of Epidemiology, University of Washington, Seattle, Washington, USA.
J Infect Dis. 2003 Feb 15;187(4):650-7. doi: 10.1086/367992. Epub 2003 Jan 29.
Many cases of mucopurulent cervicitis (MPC) are idiopathic and cannot be attributed to the known cervical pathogens Neisseria gonorrhoeae, Chlamydia trachomatis, or herpes simplex virus. Because Mycoplasma genitalium is associated with nongonoccocal urethritis in men, its role in MPC, the corresponding syndrome in women, was investigated. Archived cervical specimens from women recruited in the Harborview Sexually Transmitted Disease Clinic in Seattle from 1984 to 1986 were tested, using polymerase chain reaction, in a study that identified other causes of and risk factors for MPC. M. genitalium was detected in 50 (7.0%) of 719 women. Young age, multiple recent partners, prior miscarriage, smoking, menstrual cycle, and douching were positively associated with M. genitalium, whereas bacterial vaginosis and cunnilingus were negatively associated. After adjustment for age, phase of menstrual cycle, and presence of known cervical pathogens, women with M. genitalium had a 3.3-fold greater risk (95% confidence interval, 1.7-6.4) of MPC, which suggests that this organism may be a cause of MPC.
许多黏液脓性宫颈炎（MPC）病例病因不明，无法归因于已知的宫颈病原体淋病奈瑟菌、沙眼衣原体或单纯疱疹病毒。由于生殖支原体与男性非淋菌性尿道炎有关，因此对其在女性相应综合征MPC中的作用进行了研究。在一项确定MPC其他病因和危险因素的研究中，使用聚合酶链反应对1984年至1986年在西雅图海港景性传播疾病诊所招募的女性的存档宫颈标本进行了检测。在719名女性中，有50名（7.0%）检测出生殖支原体。年轻、近期有多个性伴侣、既往流产史、吸烟、月经周期和灌洗与生殖支原体呈正相关，而细菌性阴道病和口交则呈负相关。在对年龄、月经周期阶段和已知宫颈病原体的存在进行调整后，感染生殖支原体的女性患MPC的风险高3.3倍（95%置信区间，1.7 - 6.4），这表明该病原体可能是MPC的病因之一。
