Roth K S, Hwang S M, Segal S
Biochim Biophys Acta. 1976 Apr 5;426(4):675-87. doi: 10.1016/0005-2736(76)90132-2.
ALPHA-Methyl-D-glucoside has been used to study the invitro mechanism of the effect of maleic acid on sugar transport, using isolated rat renal tubule fragments. 6 mM maleate maximally inhibits the ability of the tubule to establish a concentration gradient for this model sugar with no evidence of ultrastructural changes. This inhibition is due to a 100% increase in efflux, as well as to a 50% decrease in influx with more prolonged incubation. The data presented here are consistent with those of other workers, but their work does not explain our results, which therefore deserve further investigation by other techniques.
α-甲基-D-葡萄糖苷已被用于研究马来酸对糖转运影响的体外机制，采用的是分离的大鼠肾小管片段。6 mM马来酸盐最大程度地抑制了肾小管为这种模型糖建立浓度梯度的能力，且无超微结构变化的证据。这种抑制是由于流出增加了100%，以及随着孵育时间延长流入减少了50%。此处呈现的数据与其他研究者的数据一致，但他们的研究无法解释我们的结果，因此这些结果值得用其他技术作进一步研究。
