Khan M A U, Ashfaq M K, Zuberi H S, Mahmood M S, Gilani A H
Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi-74800, Pakistan.
Phytother Res. 2003 Feb;17(2):183-6. doi: 10.1002/ptr.1146.
The effect of an aqueous extract of Nigella sativa seeds was studied on candidiasis in mice. An intravenous inoculum of Candida albicans produced colonies of the organism in the liver, spleen and kidneys. Treatment of mice with the plant extract (6.6 mL/kg equivalent to 5 mg of estimated protein, once daily for 3 days) 24 h after the inoculation caused a considerable inhibitory effect on the growth of the organism in all organs studied. A 5-fold decrease in Candida in kidneys, 8-fold in liver and 11-fold in spleen was observed in the groups of animals post-treated with the plant extract. Histopathological examination of the respective organs confirmed these findings. These results indicate that the aqueous extract of Nigella sativa seeds exhibits inhibitory effect against candidiasis and this study validates the traditional use of the plant in fungal infections.
研究了黑种草籽水提取物对小鼠念珠菌病的影响。静脉注射白色念珠菌接种物后，该生物体在肝脏、脾脏和肾脏中形成菌落。接种24小时后，用植物提取物（6.6 mL/kg，相当于5 mg估计蛋白质，每日一次，共3天）治疗小鼠，对所研究的所有器官中的生物体生长产生了相当大的抑制作用。在接受植物提取物后处理的动物组中，观察到肾脏中的念珠菌减少了5倍，肝脏中减少了8倍，脾脏中减少了11倍。对各个器官的组织病理学检查证实了这些发现。这些结果表明，黑种草籽水提取物对念珠菌病具有抑制作用，本研究验证了该植物在真菌感染中的传统用途。
