Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk, Abrahama Str. 58, 80-307 Gdansk, Poland.
Biovico Sp. z o.o., Hutnicza Str. 15 B, 81-061 Gdynia, Poland.
Molecules. 2021 Oct 24;26(21):6419. doi: 10.3390/molecules26216419.
L. is cultivated in many regions and its seeds have found use in variety of foods, but also in traditional medicine due to high content of biologically active essential oils. In this work optimization of supercritical carbon dioxide extraction from seeds was performed using response surface methodology to describe the influence of extraction conditions on oil yield. Kinetics of oil and thymoquinone extraction were analyzed as well. It was demonstrated that in order to collect thymoquinone-rich oil fraction, appropriate for health-related applications, the extraction should be carried out at 40 °C and 10-15 MPa. Following application of higher pressure of 35 MPa enables effective extraction of remaining oil rich in polyunsaturated fatty acids suitable for use in food industry. Thymoquinone-dependent antibacterial activity of the seed oil was observed against bacterial pathogens: and .
莳萝在许多地区都有种植，其种子在各种食品中得到了应用，也在传统医学中得到了应用，因为其含有高含量的生物活性精油。在这项工作中，使用响应面法对超临界二氧化碳从莳萝种子中的提取进行了优化，以描述提取条件对油产量的影响。还分析了油和百里醌提取的动力学。结果表明，为了收集适合健康相关应用的富含百里醌的莳萝油馏分，提取应在 40°C 和 10-15 MPa 下进行。在应用更高的 35 MPa 压力后，可以有效地提取富含多不饱和脂肪酸的剩余油，适用于食品工业。观察到莳萝籽油的百里醌依赖性抗菌活性对细菌病原体：和。
