Bashir Muhammad Usman, Qureshi Hamid Javaid
Department of Physiology, Services Institute of Medical Sciences, Lahore, Pakistan.
J Coll Physicians Surg Pak. 2010 Jul;20(7):464-7.
To determine the analgesic effect of ethanolic extract of Nigella sativa seeds on experimentally-induced pain in albino mice.
Randomized controlled trial (RCT).
Physiology Department, Services Institute of Medical Sciences (SIMS), Lahore, from May to September, 2009.
The study was carried out in 90 male albino mice using acetic acid induced writhing test as a chemical model of nociception. The mice were divided in three groups of 30 each. Group A was given normal saline (control); group B was given Nigella sativa seed extract in a dose of 50 mg/kg; and group C received diclofenac sodium, as a reference drug. Number of writhings in treated and control groups were compared.
The ethanolic extract of Nigella sativa seeds given intraperitoneally caused significant (p < 0.05) analgesic effect on nociceptive response initiated by 0.6% acetic acid; although this analgesic effect was less than that produced by diclofenac sodium.
Ethanolic extract of Nigella sativa possessed significant analgesic effect in mice.
确定黑种草籽乙醇提取物对实验诱导的白化病小鼠疼痛的镇痛作用。
随机对照试验（RCT）。
2009年5月至9月，拉合尔医学科学服务研究所生理系。
本研究以醋酸诱导扭体试验作为伤害感受的化学模型，对90只雄性白化病小鼠进行研究。将小鼠分为三组，每组30只。A组给予生理盐水（对照组）；B组给予剂量为50mg/kg的黑种草籽提取物；C组接受双氯芬酸钠作为参比药物。比较治疗组和对照组的扭体次数。
腹腔注射黑种草籽乙醇提取物对0.6%醋酸引发的伤害性反应产生了显著（p<0.05）的镇痛作用；尽管这种镇痛作用小于双氯芬酸钠产生的作用。
黑种草籽乙醇提取物对小鼠具有显著的镇痛作用。
