前列腺素E1、缓激肽和组胺对犬滑膜血管通透性的影响。
The effects of prostaglandin E1, bradykinin and histamine on canine synovial vascular permeability.
作者信息
Grennan D M, Mitchel W, Miller W, Zeitlin I J
出版信息
Br J Pharmacol. 1977 Jun;60(2):251-4. doi: 10.1111/j.1476-5381.1977.tb07747.x.
Abstract
1 The relative effects of prostaglandin E1, bradykinin and histamine on canine synovial vascular permeability were investigated by a method based on the measurement of the amounts of radiolabelled dextran (molecular weight 20,000) leaking from the circulation into the synovial cavity. 2 Bradykinin, prostaglandin E1 and histamine in that order of potency all increased synovial vascular permeability. Threshold concentrations were 0.3 micrometer, 3 micrometer and 30 micrometer respectively. 3 The effects of infusion of prostaglandin E1 combined with either bradykinin or histamine were greater than mere summation.
摘要
- 通过一种基于测量从循环系统漏入滑膜腔的放射性标记葡聚糖（分子量20,000）量的方法，研究了前列腺素E1、缓激肽和组胺对犬滑膜血管通透性的相对影响。2. 缓激肽、前列腺素E1和组胺按效力顺序均增加滑膜血管通透性。阈值浓度分别为0.3微米、3微米和30微米。3. 前列腺素E1与缓激肽或组胺联合输注的效果大于简单相加。
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本文引用的文献
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Bradykinin.缓激肽
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