Bieger W, Martin-Achard A, Bassler M, Kern H F
Cell Tissue Res. 1976 Jan 28;165(4):435-53. doi: 10.1007/BF00224474.
Prolonged secretory stimulation of the exocrine pancreas in the rat by in vivo infusion of caerulein leads to a rapid degranulation of the organ associated with a progressive reduction in the size of the zymogen granules. During the first six to twelve hours of stimulation Golgi complexes are enlarged and several structural forms of multivesicular bodies are found indicating a lysosomal degradation of membrane material in the Golgi area. Maximum secretory activity is obtained after a 24 hour infusion, Golgi complexes appear fragmented, the secretory granules measure only 1/3 to 1/4 their normal size. Thereafter, in spite of a continuous stimulation, the exocrine cells regranulate progressively up to 72 hours of infusion. This regranulation is associated with massive enlargement of the Golgi complexes.
通过体内输注蛙皮素对大鼠外分泌胰腺进行长时间的分泌刺激，会导致该器官迅速脱颗粒，同时酶原颗粒大小逐渐减小。在刺激的最初6至12小时内，高尔基体复合体增大，并发现了几种多泡体的结构形式，这表明高尔基体区域的膜材料发生了溶酶体降解。输注24小时后获得最大分泌活性，高尔基体复合体出现碎片化，分泌颗粒大小仅为正常大小的1/3至1/4。此后，尽管持续刺激，但外分泌细胞在输注72小时前会逐渐重新形成颗粒。这种重新形成颗粒与高尔基体复合体的大量增大有关。
