Dahlén G, Berg K
Clin Genet. 1976 Mar;9(3):357-64. doi: 10.1111/j.1399-0004.1976.tb01587.x.
Thirty, presumably healthy, middle-aged males from Northern Sweden were studied in September 1973 and again in February 1975. Mean fasting cholesterol and triglyceride concentrations were significantly higher at the latter investigation than they were at the former in the total group and in the Lp(a+) group, but not among those who were Lp(a-). Furthermore, estimation of free thyroxine factor yielded significantly higher results in the Lp(a-) than in the Lp(a+) group. In a previous paper, we reported significant differences between Lp(a+) and Lp(a-) individuals with respect to the relationships between insulin level and blood glucose concentration, and between insulin level and fasting triglyceride concentration. The combined results of the present and previous studies suggest that inherited metabolic differences exist between Lp(a+) and Lp(a-) individuals. In view of the association which has been found between the phenotype Lp(a+) and coronary heart disease it seems plausible that these differences may be of clinical importance.
1973年9月，对30名来自瑞典北部、推测健康的中年男性进行了研究，并于1975年2月再次进行研究。在后一次调查中，全组以及Lp(a+)组的平均空腹胆固醇和甘油三酯浓度显著高于前一次调查，但Lp(a-)组则不然。此外，游离甲状腺素因子的测定结果在Lp(a-)组显著高于Lp(a+)组。在之前的一篇论文中，我们报告了Lp(a+)和Lp(a-)个体在胰岛素水平与血糖浓度之间的关系，以及胰岛素水平与空腹甘油三酯浓度之间的关系上存在显著差异。本研究和之前研究的综合结果表明，Lp(a+)和Lp(a-)个体之间存在遗传代谢差异。鉴于已发现Lp(a+)表型与冠心病之间的关联，这些差异可能具有临床重要性这一点似乎是合理的。
