Dahlén G, Berg K, Ericson C, Noer G
Acta Med Scand. 1975 Oct;198(4):263-7. doi: 10.1111/j.0954-6820.1975.tb19537.x.
Previous studies have shown that a slow-moving pre-beta-lipoprotein fraction, named the pre-beta1-lipoprotein, occurred significantly more frequently among subjects with coronary heart disease (CHD) than among healthy individuals. This lipoprotein is closely related to, and probably identical with, the Lp(a) lipoprotein. Immunological tests likewise showed that Lp(a) lipoprotein was significantly more common among patients with CHD than among controls. Mean cholesterol and triglyceride levels were higher in pre-beta1-lipoprotein positive than in pre-beta1-lipoprotein negative individuals. Lp(a+) individuals tended to have higher serum cholesterol values than did Lp(a-) persons but there was no difference in the mean triglyceride value. This apparent discrepancy seems to be due to the presence in occasional sera of lipoprotein fractions with pre-beta1-mobility, usually of a VLDL nature. These lipoproteins are not associated with the Lp(a) lipoprotein.
先前的研究表明，一种移动缓慢的前β-脂蛋白组分，即前β1-脂蛋白，在冠心病（CHD）患者中出现的频率显著高于健康个体。这种脂蛋白与Lp(a)脂蛋白密切相关，可能是相同的。免疫学检测同样表明，Lp(a)脂蛋白在CHD患者中比在对照组中更为常见。前β1-脂蛋白阳性个体的平均胆固醇和甘油三酯水平高于前β1-脂蛋白阴性个体。Lp(a+)个体的血清胆固醇值往往高于Lp(a-)个体，但平均甘油三酯值没有差异。这种明显的差异似乎是由于偶尔的血清中存在具有前β1迁移率的脂蛋白组分，通常具有极低密度脂蛋白（VLDL）的性质。这些脂蛋白与Lp(a)脂蛋白无关。
