Singhal Amitalh, Ghosh Partha, Khan Shahid Anis
Department of Elderly Care, Lister Hospital, Corey's Mill Lane, Stevenage, Hertfordshire SG1 4AB, UK.
Age Ageing. 2003 Mar;32(2):224-5. doi: 10.1093/ageing/32.2.224.
Amiodarone is a commonly used anti-arrhythmic in elderly patients. Abnormal liver function is frequently reported with its use but clinically symptomatic disease is rare. Hepatomegaly, cholestasis, acute hepatitis and rarely fulminant liver failure have been recorded [1, 2], however amiodarone toxicity presenting with cirrhosis is exceedingly rare. Toxic effects of amiodarone are well described with higher dosage but severe hepatic toxicity and cirrhosis with low dose amiodarone has not been reported in the English language literature. We present a report on a patient with pseudo-alcoholic cirrhosis with low dose amiodarone.
胺碘酮是老年患者常用的抗心律失常药物。使用该药时肝功能异常的报告屡见不鲜，但临床上出现症状性疾病的情况却很少见。已有肝肿大、胆汁淤积、急性肝炎的记录，暴发性肝衰竭则罕见[1,2]，然而胺碘酮毒性表现为肝硬化极为罕见。胺碘酮的毒性在高剂量时已有充分描述，但低剂量胺碘酮导致严重肝毒性和肝硬化的情况在英文文献中尚未见报道。我们报告一例低剂量胺碘酮致假酒精性肝硬化患者。
