结外恶性淋巴瘤在牙龈处发生自发消退。
Spontaneous regression of extranodal malignant lymphoma occurred in the gingiva.
作者信息
Koga Makoto, Kusukawa Jingo, Hayabuchi Naofumi
机构信息
Dental and Oral Medical Center, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan.
出版信息
Oral Oncol. 2003 Apr;39(3):323-4. doi: 10.1016/s1368-8375(02)00122-7.
The spontaneous regression of malignant neoplasm is an extremely rare event. Here we report a case of extranodal malignant lymphoma occurring in the upper gingiva, which regressed spontaneously. A 78-year-old female had noticed a diffuse bucco-lingual swelling of the left maxillary gingiva in the incisor regions for a month, and she visited our department on 20 January 1999. Intraoral examination revealed diffuse swelling and redness in the maxillary gingiva of the incisor regions. Cervical and underarm lymphadenopathy was not detected. Surgical biopsy of the swollen gingiva revealed a malignant lymphoma, with diffuse large cells, B cell type. She was clinically staged as IE. After biopsy, the tumor spontaneously decreased in size; finally, the mass completely disappeared after 3 weeks. After regression, the lesions were externally irradiated with 30 Gy total dose. The patient has been free from disease for 36 months after regression.
恶性肿瘤的自发消退是极为罕见的事件。在此我们报告一例发生于上颌牙龈的结外恶性淋巴瘤自发消退的病例。一名78岁女性注意到上颌切牙区左侧牙龈出现弥漫性颊舌侧肿胀1个月，于1999年1月20日前来我科就诊。口腔检查发现切牙区上颌牙龈弥漫性肿胀及发红。未检测到颈部及腋窝淋巴结肿大。对肿胀牙龈进行手术活检，结果显示为恶性淋巴瘤，弥漫大细胞型，B细胞型。临床分期为IE期。活检后，肿瘤大小自发减小；最终，肿块在3周后完全消失。消退后，对病变部位进行了总量30 Gy的外照射。患者在消退后已无病生存36个月。
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