Kazerooni T, Hamze-Nejadi S
Shiraz University of Medical Sciences, Shiraz, Iran.
Int J Gynaecol Obstet. 2003 Mar;80(3):279-83. doi: 10.1016/s0020-7292(02)00382-x.
Based on the fact that urinary calcium excretion decreases in pre-eclampsia, this study was designed to determine the predictive value of calcium to creatinine ratio in a spot urine sample.
The calcium to creatinine ratio was measured in a spot urine sample of 102 normotensive women at 20-24 weeks' gestation who attended the prenatal care clinic of the Shiraz University of Medical Sciences. The women were followed-up until delivery and grouped according to pre-eclampsia occurrence. The prevalence of pre-eclampsia was measured and compared with the calcium to creatinine ratio.
Ninety-four women remained normotensive during pregnancy and eight developed pre-eclampsia. Mean age, gestational age at the beginning of the study, and gestational age at delivery did not differ significantly between the two groups. Mean urinary calcium concentration (15.9+/-8.5 mg/dl in normotensive vs. 10.2+/-7.5 mg/dl in pre-eclamptic women), and mean birth weight (3192+/-336.3 g vs. 2712+/-468.9 g) were significantly lower in pre-eclamptic patients (P=0.03 and 0.005, respectively). Mean calcium to creatinine ratio was also significantly lower in the pre-eclamptic group (P<0.03).
Single urine calcium to creatinine ratio may be an effective method for screening women at greatest risk for pre-eclampsia.
基于子痫前期尿钙排泄减少这一事实，本研究旨在确定随机尿样中钙肌酐比值的预测价值。
对102名在设拉子医科大学产前保健诊所就诊的妊娠20 - 24周的血压正常女性的随机尿样进行钙肌酐比值测定。对这些女性进行随访直至分娩，并根据子痫前期的发生情况进行分组。测量子痫前期的患病率，并与钙肌酐比值进行比较。
94名女性孕期血压一直正常，8名发生了子痫前期。两组间平均年龄、研究开始时的孕周和分娩时的孕周无显著差异。子痫前期患者的平均尿钙浓度（血压正常者为15.9±8.5mg/dl，子痫前期患者为10.2±7.5mg/dl）和平均出生体重（分别为3192±336.3g和2712±468.9g）显著更低（P分别为0.03和0.005）。子痫前期组的平均钙肌酐比值也显著更低（P<0.03）。
单次尿钙肌酐比值可能是筛查子痫前期高危女性的有效方法。
