分布容积随时间的变化情况。

J Pharm Sci. 1976 Mar;65(3):452-4. doi: 10.1002/jps.2600650339.

A single definition for all volume terms in pharmacokinetic modeling is proposed; this parameter is considered as a function of time. This definition will represent the kinetic nature of pharmacokinetic models and will provide a highly sensitive parameter for correlation with pharmacological responses.

提出了药代动力学建模中所有体积项的单一定义；该参数被视为时间的函数。此定义将体现药代动力学模型的动力学性质，并将提供一个与药理反应相关的高灵敏度参数。