Kubo Y, Ono T, Iwamoto N, Yajima I
Jpn J Antibiot. 1976 Jan;29(1):17-21.
The following results were obtained from treatment of 29 cases of lower urinary tract infections with amoxicillin. 1. Amoxicillin was remarkably effective in 13 cases of acute cystitis, in terms of effect according to dose and bacterial species. 2. The effective rate of amoxicillin in 10 cases of chronic cystitis amounted only to 30% due to complications and resistant bacteria. (The group given 1,500 mg/day was a little higher in the effective rate than the 750 mg/day group.) 3. Amoxicillin was low in effect against infections with Pseudomonas aeruginosa and hardly effective against bacteria resistant to amoxicillin. 4. So far as this study is concerned, amoxicillin produced good clinical results at a half dose of ampicillin, as in the fundamental experiment. 5. Any severe side effect was observed in no case.
用阿莫西林治疗29例下尿路感染获得了以下结果。1. 根据剂量和细菌种类,阿莫西林对13例急性膀胱炎疗效显著。2. 由于并发症和耐药菌,阿莫西林对10例慢性膀胱炎的有效率仅为30%。(每日服用1500mg组的有效率略高于每日服用750mg组。)3. 阿莫西林对铜绿假单胞菌感染效果不佳,对耐阿莫西林的细菌几乎无效。4. 就本研究而言,与基础实验一样,阿莫西林以氨苄西林一半的剂量产生了良好的临床效果。5. 未观察到任何严重副作用。