Müller Gerd, Lipp Martin
Department of Molecular Tumor Genetics and Immunogenetics, Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13092 Berlin, Germany.
Curr Opin Immunol. 2003 Apr;15(2):217-24. doi: 10.1016/s0952-7915(03)00014-1.
Chemokines are essential regulators of lymphocyte migration throughout the body. The chemokine system controls lymphocyte recirculation in immune-system homeostasis, as well as the activation-dependent and tissue-selective trafficking of effector and memory lymphocytes during immune responses. In addition, there is now substantial evidence that chemokines are critical factors for the development and organization of secondary lymphoid organs and that they are involved in all stages of lymphoid organogenesis.
趋化因子是淋巴细胞在全身迁移的重要调节因子。趋化因子系统在免疫系统稳态中控制淋巴细胞再循环，以及在免疫反应期间效应淋巴细胞和记忆淋巴细胞的激活依赖性和组织选择性运输。此外，现在有大量证据表明，趋化因子是次级淋巴器官发育和组织的关键因素，并且它们参与淋巴器官发生的所有阶段。
