Mattenberger Yves, James Dominic I, Martinou Jean Claude
Department of Cell Biology, University of Geneva, Quai Ernest-Ansermet 30, Geneva, Switzerland
FEBS Lett. 2003 Mar 13;538(1-3):53-9. doi: 10.1016/s0014-5793(03)00124-8.
Mitochondrial fusion is a poorly characterized process which has mainly been studied in yeast and Drosophila but is thought to occur in all eukaryotes. Until now, there was only indirect evidence to support such a process in mammalian cells. In this study, using a cell fusion system, we found that mitochondrial fusion occurs rapidly in mammalian cells and is completed in less than 24 h. We report that the fusion of mitochondria requires an intact mitochondrial inner membrane potential but is independent of a functional cytoskeleton.
线粒体融合是一个特征描述较少的过程，主要在酵母和果蝇中进行了研究，但被认为在所有真核生物中都会发生。到目前为止，在哺乳动物细胞中仅有间接证据支持这一过程。在本研究中，我们利用细胞融合系统发现线粒体融合在哺乳动物细胞中迅速发生，且在不到24小时内完成。我们报告线粒体融合需要完整的线粒体内膜电位，但与功能性细胞骨架无关。
