Rumpf K W, Frenzel S, Lowitz H D, Scheler F
Klin Wochenschr. 1976 Mar 15;54(6):255-9. doi: 10.1007/BF01468920.
The influence of indomethacin, a potent inhibitor of prostaglandin synthesis, on basal and stimulated plasma renin activities in normal human subjects was determined. Stimulation of the renin activity was achieved by orthostasis or by furosemide. Indomethacin led to a considerable decrease of both basal and stimulated plasma renin activity in chronic and acute experiments. Our experiments provide no evidence that major changes in the sodium balance are responsible for the effects observed. It is concluded that some antagonistic function of the renin angiotensin system and prostaglandins seems probable. These antagonistic actions might play a role in the regulation of the kidney circulation or the arterial blood pressure.
研究了强效前列腺素合成抑制剂吲哚美辛对正常人体基础和刺激状态下血浆肾素活性的影响。通过直立位或速尿刺激肾素活性。在慢性和急性实验中，吲哚美辛均导致基础和刺激状态下的血浆肾素活性显著降低。我们的实验没有证据表明钠平衡的主要变化是观察到的这些效应的原因。结论是肾素-血管紧张素系统和前列腺素之间似乎存在某种拮抗作用。这些拮抗作用可能在肾循环或动脉血压的调节中起作用。
