Pedrinelli R, Arzilli F, Cavasinni L, Poli L, Sassano P, Salvetti A
J Endocrinol Invest. 1978 Oct;1(4):315-20. doi: 10.1007/BF03350976.
The effect of indomethacin on plasma renin activity (PRA), urinary aldosterone, 17 OH ketogenic steroids and plasma cortisol was studied in twenty-three patients with essential hypertension and compared in eleven patients to oxprenolol effect by 2 x 2 factorial trial. Indomethacin decreased PRA and urinary aldosterone: its effect was maintained when the drug was given for three days and it was related to basal PRA and aldosterone values. Therefore in patients with low PRA (renin-sodium index) PRA and aldosterone were unchanged, while they decreased in the normal high PRA group. Aldosterone changes were related to those of PRA, while 17 OH ketogenic steroids and plasma cortisol were unchanged. Both indomethacin and oxprenolol decreased PRA, but no interaction or additive effect was found between the two drugs. The present data indicate that indomethacin can decrease both PRA and aldosterone to an extent which is related to basal values and that aldosterone changes are mainly explained by those of PRA. The PRA unresponsiveness to indomethacin found in low renin patients may suggest renal prostaglandin deficiency. Finally the lack of interaction or of additive effect between indomethacin and oxprenolol may be explained by postulating either that the two drugs act on a common pathway or that an additive effect on PRA cannot be detected renin being maximally suppressed by full renal beta-receptors blockade.
在23例原发性高血压患者中研究了消炎痛对血浆肾素活性（PRA）、尿醛固酮、17-羟酮类固醇和血浆皮质醇的影响，并通过2×2析因试验在11例患者中将其与心得平的作用进行比较。消炎痛降低PRA和尿醛固酮：给药三天时其作用仍持续存在，且与基础PRA和醛固酮值有关。因此，在PRA较低（肾素-钠指数）的患者中，PRA和醛固酮无变化，而在正常高PRA组中它们降低。醛固酮的变化与PRA的变化相关，而17-羟酮类固醇和血浆皮质醇无变化。消炎痛和心得平均降低PRA，但未发现两种药物之间有相互作用或相加作用。目前的数据表明，消炎痛可降低PRA和醛固酮，其程度与基础值有关，且醛固酮的变化主要由PRA的变化所解释。在低肾素患者中发现PRA对消炎痛无反应可能提示肾前列腺素缺乏。最后，消炎痛和心得平之间缺乏相互作用或相加作用，可通过假设两种药物作用于共同途径，或通过完全肾β受体阻断使肾素被最大程度抑制而无法检测到对PRA的相加作用来解释。
