Elshafie Hazem S, Caputo Lucia, De Martino Laura, Sakr Shimaa H, De Feo Vincenzo, Camele Ippolito
School of Agricultural, Forestry, Food and Environmental Sciences (SAFE), University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
Plants (Basel). 2021 Jan 14;10(1):153. doi: 10.3390/plants10010153.
Pomegranate ( L.) fruits are important sources of vitamins and minerals and widely used in the dietary supplement industry. An aqueous extract of its leathery exocarp (LEP) was obtained by a solid-phase micro-extraction method. The antifungal activity was examined against the phytopathogenic fungi, , , and , and the antibacterial activity was evaluated against , and . The antimicrobial assays showed, in some cases, a promising antimicrobial effect compared to the synthetic drugs. The possible anti-acetylcholinesterase and antioxidant activities of the LEP extract were investigated by the Ellman's assay and 2,2-diphenyl-1-picrylhydrazyl (DPPH) test, respectively, and their results showed that the LEP extract has an effective anti-acetylcholinesterase inhibitory effect and an antioxidant activity. Thus, the LEP extract could be valid as a candidate for further studies on the use of pomegranate in neurodegenerative diseases as a food preservative and a suitable substitute to control several phytopathogens.
石榴（L.）果实是维生素和矿物质的重要来源，在膳食补充剂行业中广泛使用。通过固相微萃取法获得了其坚韧外果皮（LEP）的水提取物。检测了其对植物病原真菌、、、的抗真菌活性，并评估了对、和的抗菌活性。抗菌试验表明，在某些情况下，与合成药物相比，具有有前景的抗菌效果。分别通过埃尔曼法和2,2-二苯基-1-苦基肼基（DPPH）试验研究了LEP提取物可能的抗乙酰胆碱酯酶和抗氧化活性，结果表明LEP提取物具有有效的抗乙酰胆碱酯酶抑制作用和抗氧化活性。因此，LEP提取物可作为进一步研究石榴在神经退行性疾病中作为食品防腐剂以及控制多种植物病原体的合适替代品的有效候选物。
