Cotter Bruno R
University of California, San Diego, Division of Cardiology, UCSD Medical Center, San Diego, CA 92103-8411, USA.
Prog Cardiovasc Dis. 2003 Jan-Feb;45(4):319-26. doi: 10.1053/pcad.2003.5.
The heart is an organ frequently affected in patients with acquired immune deficiency syndrome (AIDS). Since the introduction of highly active antiretroviral therapy (HAART), a sharp decline in mortality and morbidity has been observed in human immunodeficiency virus (HIV)-infected patients. However, numerous reports of myocardial infarcts in young HIV-infected patients have raised concerns of premature coronary artery disease in this population. New risk factors for coronary heart disease such as increased insulin resistance, dyslipidemia, and lipodystrophy syndrome, which are associated with HAART, may accelerate underlying arteriosclerosis in HIV-infected patients. Data on the incidence of coronary heart disease are limited to case reports and retrospective studies. Results from ongoing, large, prospective studies will provide information on whether or not HAART may increase the incidence of myocardial infarcts and whether a drastic change in HIV therapy is warranted.
心脏是获得性免疫缺陷综合征（艾滋病）患者常受影响的器官。自从高效抗逆转录病毒疗法（HAART）问世以来，已观察到人类免疫缺陷病毒（HIV）感染患者的死亡率和发病率急剧下降。然而，众多关于年轻HIV感染患者心肌梗死的报告引发了对该人群过早发生冠状动脉疾病的担忧。与HAART相关的冠心病新危险因素，如胰岛素抵抗增加、血脂异常和脂肪代谢障碍综合征，可能会加速HIV感染患者潜在的动脉硬化。关于冠心病发病率的数据仅限于病例报告和回顾性研究。正在进行的大型前瞻性研究结果将提供信息，以确定HAART是否可能增加心肌梗死的发病率，以及是否有必要对HIV治疗进行重大改变。
