Badami Shrishailappa, Gupta Mahesh Kumar, Suresh B
Department of Pharmaceutical Chemistry, J.S.S. College of Pharmacy, Rocklands, Ootacamund 643 001, Tamilnadu, India.
J Ethnopharmacol. 2003 Apr;85(2-3):227-30. doi: 10.1016/s0378-8741(03)00021-7.
Plants containing flavonoids have been reported to possess strong antioxidant properties. The ethanolic extract of Striga orobanchioides was screened for in vitro and in vivo antioxidant properties using standard procedures. The ethanol extract exhibited IC(50) values of 18.65+/-1.46 and 11.20+/-0.52 micro g/ml, respectively in DPPH and nitric oxide radical inhibition assays. These values were less than those obtained for ascorbic acid and rutin, used as standards. In the in vivo experiments the extract treatment at 100mg/kg body weight dose caused a significant increase in the level of the catalase in the liver and the kidneys. A significant increase in the level of SOD in the liver was observed. The treatment also caused a significant decrease in the TBA-RS and increase in the ascorbic acid levels. These results suggest strong antioxidant potentials of the ethanolic extract of S. orobanchioides.
据报道，含有类黄酮的植物具有很强的抗氧化特性。使用标准程序对独脚金（Striga orobanchioides）的乙醇提取物进行了体外和体内抗氧化特性筛选。在DPPH和一氧化氮自由基抑制试验中，乙醇提取物的IC(50)值分别为18.65±1.46和11.20±0.52微克/毫升。这些值低于用作标准的抗坏血酸和芦丁的值。在体内实验中，以100毫克/千克体重剂量进行提取物处理，导致肝脏和肾脏中过氧化氢酶水平显著增加。观察到肝脏中SOD水平显著增加。该处理还导致硫代巴比妥酸反应物（TBA-RS）显著降低和抗坏血酸水平增加。这些结果表明独脚金乙醇提取物具有很强的抗氧化潜力。
