来自白桂木茎皮的生物活性异戊烯基黄酮类化合物。
Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando.
作者信息
Seo Eun-Kyoung, Lee Dongho, Shin Young Geun, Chai Hee-Byung, Navarro Hernán A, Kardono Leonardus B S, Rahman Ismail, Cordell Geoffrey A, Farnsworth Norman R, Pezzuto John M, Kinghorn A Douglas, Wani Mansukh C, Wall Monroe E
机构信息
Chemistry and Life Sciences, Research Triangle Institute, PO Box 12194, Research Triangle Park, North Carolina 27709, USA.
出版信息
Arch Pharm Res. 2003 Feb;26(2):124-7. doi: 10.1007/BF02976656.
Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.
通过以DNA链断裂和KB细胞毒性试验为监测指标的生物活性导向分离法，从白桂木的茎皮中分离出4种已知的异戊烯基黄酮类化合物，即雅顿宁E（1）、雅顿宁O（2）、白桂木氧杂蒽酮（3）和环白桂木氧杂蒽酮（4）。化合物1和3表现出较强的DNA链断裂活性，且发现所有4种化合物均具有细胞毒性。
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