Artocarpus rigida 的细胞毒性和 NF-κB 抑制成分。

Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida.

机构信息

Division of Medicinal Chemistry and Pharmacognosy and Division of Pharmacy Practice and Administration, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA.

出版信息

J Nat Prod. 2010 May 28;73(5):949-55. doi: 10.1021/np1002065.

DOI:10.1021/np1002065

PMID:20384315

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2878397/

Abstract

Four new prenylated flavonoids (1-4), a new stilbenoid (5), and nine known compounds were isolated from the twigs of Artocarpus rigida, collected in Indonesia. The structures of the new compounds were determined by analysis of their spectroscopic data, and the absolute configuration at C-12 of 1 and 2 and the known compounds artonin O (6), artobiloxanthone (7), and cycloartobiloxanthone (8) was determined from their CD and NMR spectroscopic data. Several of the compounds obtained were cytotoxic toward HT-29 human colon cancer cells, with the most potent being compound 2 and the known compounds 6 and 8. Of the substances obtained, compounds 1 and 7 were the most active in the NF-kappaB p50 and p65 assay, respectively.

摘要

从印度尼西亚采集的粗榧枝条中分离得到了四个新的prenylated 黄酮类化合物（1-4），一个新的stilbenoid（5）和九个已知化合物。新化合物的结构通过分析其光谱数据确定，并且 1 和 2 以及已知化合物 artonin O（6），arto biloxanthone（7）和 cycloartobiloxanthone（8）的 C-12 的绝对构型是从它们的 CD 和 NMR 光谱数据确定的。获得的几种化合物对 HT-29 人结肠癌细胞具有细胞毒性，其中最有效的是化合物 2 和已知化合物 6 和 8。在所获得的物质中，化合物 1 和 7 在 NF-κB p50 和 p65 测定中分别最活跃。