来自黑叶波罗蜜树枝的异戊烯基黄酮类化合物。

Prenylflavonoids from the Twigs of Artocarpus nigrifolius.

作者信息

Liu Xi, Kuang Xiao-Dong, He Xiao-Ru, Ren Gang, Wang Yong, Xu Liu-Yun, Feng Li-Hua, Wang Bin, Zhou Zhi-Wang

机构信息

School of Pharmacy, Nanchang University.

School of Basic Medical Sciences, Nanchang University.

出版信息

Chem Pharm Bull (Tokyo). 2018;66(4):434-438. doi: 10.1248/cpb.c17-00958.

DOI:10.1248/cpb.c17-00958

PMID:29607909

Abstract

Two new prenylated flavones, artocarnin A (2) and carpachromenol (12), together with 13 known prenylflavonoids (1, 3-11, 13-15) were isolated from the twigs of Artocarpus nigrifolius for the first time. Their structures were elucidated by high resolution-electrospray ionization (HR-ESI)-MS, NMR spectroscopic analysis, and in comparison with the reported data. Compounds 1-15 were evaluated for their antiproliferative effects against SiHa and SGC-7901 human cancer cell lines in vitro. The most active compound, eleocharin A (10), showed significant cytotoxicity on SiHa cells (IC=0.7±0.1 µM) and inhibitory activity against SGC-7901 cells (IC=8.3±0.2 µM) and could be considered as potential lead compound for further development of novel anti-tumor agents.

摘要

首次从黑叶波罗蜜树枝中分离出两种新的异戊烯基黄酮，即波罗蜜黄素A（2）和卡帕色原醇（12），以及13种已知的异戊烯基黄酮（1、3 - 11、13 - 15）。通过高分辨率电喷雾电离（HR - ESI）-质谱、核磁共振光谱分析，并与已报道的数据进行比较，阐明了它们的结构。对化合物1 - 15进行了体外抗SiHa和SGC - 7901人癌细胞系增殖作用的评估。活性最强的化合物，沼生水马齿黄素A（10），对SiHa细胞显示出显著的细胞毒性（IC = 0.7±0.1 μM），对SGC - 7901细胞具有抑制活性（IC = 8.3±0.2 μM），可被视为进一步开发新型抗肿瘤药物的潜在先导化合物。