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石花菜目并非仅仅是琼脂——揭示其对皮肤疾病的抗菌潜力

Gelidiales Are Not Just Agar-Revealing the Antimicrobial Potential of for Skin Disorders.

作者信息

Matias Margarida, Pinteus Susete, Martins Alice, Silva Joana, Alves Celso, Mouga Teresa, Gaspar Helena, Pedrosa Rui

机构信息

MARE-Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal.

BioISI-Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, 1749-016 Lisboa, Portugal.

出版信息

Antibiotics (Basel). 2022 Apr 5;11(4):481. doi: 10.3390/antibiotics11040481.

DOI:10.3390/antibiotics11040481
PMID:35453232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9030148/
Abstract

In recent decades, seaweeds have proven to be an excellent source of bioactive molecules. Presently, the seaweed is harvested in a small area of the Portuguese coast exclusively for agar extraction. The aim of this work was to fully disclosure as a sustainable source of antimicrobial ingredients for new dermatological formulations, highlighting its potential to be explored in a circular economy context. For this purpose, after a green sequential extraction, these seaweed fractions (F1-F5) were chemically characterized (H NMR) and evaluated for their antimicrobial potential against , and . The most active fractions were also evaluated for their effects on membrane potential, membrane integrity and DNA damage. Fractions F2 and F3 displayed the best results, with IC values of 16.1 (7.27-23.02) μg/mL and 51.04 (43.36-59.74) μg/mL against , respectively, and 53.29 (48.75-57.91) μg/mL and 102.80 (87.15-122.30) μg/mL against , respectively. The antimicrobial effects of both fractions seem to be related to membrane hyperpolarization and DNA damage. This dual mechanism of action may provide therapeutic advantages for the treatment of skin dysbiosis-related diseases.

摘要

近几十年来，海藻已被证明是生物活性分子的优质来源。目前，仅在葡萄牙海岸的一小片区域采集这种海藻用于琼脂提取。这项工作的目的是充分揭示其作为新型皮肤病配方中抗菌成分可持续来源的潜力，突出其在循环经济背景下有待开发的潜力。为此，经过绿色连续提取后，对这些海藻组分（F1 - F5）进行了化学表征（氢核磁共振），并评估了它们对[具体菌种1]、[具体菌种2]和[具体菌种3]的抗菌潜力。还评估了活性最强的组分对膜电位、膜完整性和DNA损伤的影响。F2和F3组分显示出最佳结果，对[具体菌种1]的半数抑制浓度（IC）值分别为16.1（7.27 - 23.02）μg/mL和51.04（43.36 - 59.74）μg/mL，对[具体菌种2]的IC值分别为53.29（48.75 - 57.91）μg/mL和102.80（87.15 - 122.30）μg/mL。这两种组分的抗菌作用似乎都与膜超极化和DNA损伤有关。这种双重作用机制可能为治疗与皮肤生态失调相关的疾病提供治疗优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/9030148/f50b837192fe/antibiotics-11-00481-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/9030148/8fe5065d5be1/antibiotics-11-00481-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/9030148/3a1426c18abc/antibiotics-11-00481-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/9030148/68d97be4115f/antibiotics-11-00481-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/9030148/bbaf740c98d2/antibiotics-11-00481-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/9030148/60c9e82f8b49/antibiotics-11-00481-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/9030148/004037e693c4/antibiotics-11-00481-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/9030148/f50b837192fe/antibiotics-11-00481-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/9030148/8fe5065d5be1/antibiotics-11-00481-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/9030148/3a1426c18abc/antibiotics-11-00481-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/9030148/68d97be4115f/antibiotics-11-00481-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/9030148/bbaf740c98d2/antibiotics-11-00481-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/9030148/60c9e82f8b49/antibiotics-11-00481-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/9030148/004037e693c4/antibiotics-11-00481-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad4/9030148/f50b837192fe/antibiotics-11-00481-g007.jpg

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Pharmaceutics. 2021 Nov 15;13(11):1930. doi: 10.3390/pharmaceutics13111930.
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Mar Drugs. 2021 Oct 14;19(10):574. doi: 10.3390/md19100574.
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Cutibacterium acnes and Staphylococcus epidermidis: the unmissable modulators of skin inflammatory response.
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