去甲丙咪嗪对酒精和对乙酰氨基酚吸收的影响。
The effect of desmethylimipramine on the absorption of alcohol and paracetamol.
作者信息
Hall R C, Brown D, Carter R, Kendall M J
出版信息
Postgrad Med J. 1976 Mar;52(605):139-42. doi: 10.1136/pgmj.52.605.139.
Abstract
Many drugs can delay gastric emptying and may thereby impair the absorption of other drugs. Desmethylimipramine (DMI) is an antidepressant with anticholinergic properties which might be expected to delay the rate of gastric emptying. In five out of six subjects, DMI significantly delayed both the absorption of alcohol (assessed by a breathalyser) and of paracetamol, and there was a correlation between the two. The breathalyser can therefore be used to predict the extent to which one may impair the absorption of another drug by its effect on gastrointestinal motility.
摘要
许多药物会延缓胃排空，从而可能损害其他药物的吸收。去甲丙咪嗪（DMI）是一种具有抗胆碱能特性的抗抑郁药，预计它可能会延缓胃排空速率。在六名受试者中的五名身上，DMI显著延缓了酒精（通过呼吸分析仪评估）和对乙酰氨基酚的吸收，并且两者之间存在相关性。因此，呼吸分析仪可用于预测一种药物通过影响胃肠蠕动可能损害另一种药物吸收的程度。
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本文引用的文献
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