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通过将1,2-³H-17-羟孕酮与大鼠肾上腺线粒体一起温育制备1,2-³H-21-脱氧皮质醇。

Preparation of 1,2-3H-21-deoxycortisol by incubation of 1,2-3H-17-hydroxyprogesterone with rat adrenal mitochondria.

作者信息

Maschler I, Horn H

出版信息

Steroids. 1976 Jan;27(1):1-3. doi: 10.1016/0039-128x(76)90064-7.

DOI:10.1016/0039-128x(76)90064-7
PMID:1265788
Abstract

A method is described for preparation of 1,2-3H-21-deoxycortisol by incubation of 1,2-3H-17-hydroxyprogesterone with rat adrenal mitoochondria. The radiochemical purity of the product was established by two subsequent chromatographies, reversed isotopic dilution and oxidation to 21-deoxycortisone. The final yield of 1,2-3H-21-deoxycortisol was approximately 15%.

摘要

描述了一种通过将1,2-³H-17-羟孕酮与大鼠肾上腺线粒体一起温育来制备1,2-³H-21-脱氧皮质醇的方法。通过两次连续的色谱法、反向同位素稀释以及氧化为21-脱氧可的松来确定产物的放射化学纯度。1,2-³H-21-脱氧皮质醇的最终产率约为15%。

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