Bélanger C, Luu-The V, Dupont P, Tchernof A
Molecular Endocrinology and Oncology Research Center, Quebec, Canada.
Horm Metab Res. 2002 Nov-Dec;34(11-12):737-45. doi: 10.1055/s-2002-38265.
The present article summarizes some of the studies available on steroid hormone conversion through the specific expression of steroidogenic enzymes in adipose tissue (adipose tissue intracrinology) and discusses the potential impact of local adipose tissue steroid metabolism on the regulation of adipocyte function and other metabolic parameters. Several studies have demonstrated significant steroid hormone uptake and conversion by adipose tissues from various body sites and in various cell fractions. Activities and/or mRNAs of aromatase, 3beta-hydroxysteroid dehydrogenase (HSD), 3alpha-HSD, 11beta-HSD, 17beta-HSD, 7alpha-hydroxylase, 17alpha-hydroxylase, 5alpha-reductase and UDP-glucuronosyltransferase 2B15 have been detected in adipose tissue or adipose cells. These studies have demonstrated potentially important roles for these enzymes in obesity, central fat accumulation, and the metabolic syndrome. Future studies on adipose tissue intracrinology will contribute further to our understanding of steroid action in adipocytes.
本文总结了一些关于通过脂肪组织中类固醇生成酶的特异性表达进行类固醇激素转化的现有研究（脂肪组织内分泌学），并讨论了局部脂肪组织类固醇代谢对脂肪细胞功能调节和其他代谢参数的潜在影响。多项研究表明，来自身体不同部位和不同细胞组分的脂肪组织可大量摄取和转化类固醇激素。在脂肪组织或脂肪细胞中已检测到芳香化酶、3β-羟基类固醇脱氢酶（HSD）、3α-HSD、11β-HSD、17β-HSD、7α-羟化酶、17α-羟化酶、5α-还原酶和尿苷二磷酸葡萄糖醛酸基转移酶2B15的活性和/或mRNA。这些研究表明这些酶在肥胖、中心性脂肪堆积和代谢综合征中具有潜在的重要作用。未来关于脂肪组织内分泌学的研究将进一步有助于我们理解类固醇在脂肪细胞中的作用。
