Choi Jae-Won, Fujimaki T Susumu, Kitamura Kimiyoshi, Hashimoto Shunji, Ito Hiroyasu, Suzuki Noriyuki, Sakai Shin-ichi, Morita Masatoshi
National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba-Shi, Ibaraki 305-8506, Japan.
Environ Sci Technol. 2003 Mar 1;37(5):817-21. doi: 10.1021/es0258780.
Human adipose samples collected in Tokyo, Japan in 1970 and 2000 were analyzed for the presence of polybrominated dibenzo-p-dioxins (PBDDs), dibenzofurans (PBDFs), and diphenyl ethers (PBDEs), and the concentrations in the two groups were compared. As far as we know, the concentrations of the PBDD/Fs in adipose tissue from the general Japanese population are reported for the first time. Three PBDD/F congeners were found in the following adipose tissues: 2,3,7,8-TeBDD, 2,3,7,8-TeBDF, and 2,3,4,7,8-PeBDF. The median concentrations (ranges) of three PBDD/Fs in 1970 and 2000 were 5.1 (3.4-8.3) and 3.4 (1.9-5.3) pg/g lipid wt (l.w.), respectively. For PBDEs, seven PBDE congeners were determined in the following samples: 2,4,4'-tribromodiphenyl ether (BDE-28), 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), 2,2',4,4',5-pentabromodiphenyl ether (BDE-99), 2,2',4,4',6-pentabromodiphenyl ether (BDE-100), 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE-153), 2,2',4,4',5',6-hexabromodiphenyl ether (BDE-154), and 2,2',3,4,4',5',6-heptabromodiphenyl ether (BDE-183). Median concentrations (ranges) of PBDEs showed a significant increase from 29.2 (6.8-78.4) pg/g l.w. in 1970 to 1288 (466-2,753) pg/g l.w. in 2000. BDE-47, the major congener of PBDEs, was 56.2% and 35.6% of the total in 1970 and 2000, respectively, whereas the BDE-153 was < 1% and 29.7% of the total in 1970 and 2000, respectively. This may indicate that the source of PBDEs had changed during this period. Further analysis of archived human samples from 1970 to 2000 is needed to describe the details of the contamination trends of PBDD/Fs and PBDEs in the Japanese population. Furthermore, PBDD/F monitoring, particularly 2,3,7,8-TeBDD and 2,3,7,8-TeBDF, may give more toxicological information based on TeCDD toxic equivalents (TEQs).
对1970年和2000年在日本东京采集的人体脂肪样本进行分析，检测其中多溴二苯并对二噁英（PBDDs）、二苯并呋喃（PBDFs）和二苯醚（PBDEs）的存在情况，并比较两组样本中的浓度。据我们所知，首次报道了日本普通人群脂肪组织中PBDD/Fs的浓度。在以下脂肪组织中发现了三种PBDD/F同系物：2,3,7,8 - 四溴二苯并对二噁英（2,3,7,8-TeBDD）、2,3,7,8 - 四溴二苯并呋喃（2,3,7,8-TeBDF）和2,3,4,7,8 - 五溴二苯并呋喃（2,3,4,7,8-PeBDF）。1970年和2000年三种PBDD/Fs的中位浓度（范围）分别为5.1（3.4 - 8.3）和3.4（1.9 - 5.3）皮克/克脂质重量（l.w.）。对于PBDEs，在以下样本中测定了七种PBDE同系物：2,4,4'-三溴二苯醚（BDE - 28）、2,2',4,4'-四溴二苯醚（BDE - 47）、2,2',4,4',5 - 五溴二苯醚（BDE - 99）、2,2',4,4',6 - 五溴二苯醚（BDE - 100）、2,2',4,4',5,5'-六溴二苯醚（BDE - 153）、2,2',4,4',5',6 - 六溴二苯醚（BDE - 154）和2,2',3,4,4',5',6 - 七溴二苯醚（BDE - 183）。PBDEs的中位浓度（范围）从1970年的29.2（6.8 - 78.4）皮克/克l.w.显著增加到2000年的1288（466 - 2753）皮克/克l.w.。PBDEs的主要同系物BDE - 47在1970年和2000年分别占总量的56.2%和35.6%，而BDE - 153在1970年和2000年分别占总量的<1%和29.7%。这可能表明在此期间PBDEs的来源发生了变化。需要对1970年至2000年的存档人体样本进行进一步分析，以描述日本人群中PBDD/Fs和PBDEs污染趋势的详细情况。此外，PBDD/F监测，特别是2,3,7,8-TeBDD和2,3,7,8-TeBDF监测，基于四氯二苯并对二噁英毒性当量（TEQs）可能会提供更多毒理学信息。
