Bavarian Health and Food Safety Authority, Department of Chemical Safety and Toxicology, Pfarrstrasse 3, D-80538 Munich, Germany; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-University, Ziemssenstrasse 1, D-80336 Munich, Germany.
Bavarian Health and Food Safety Authority, Department of Chemical Safety and Toxicology, Pfarrstrasse 3, D-80538 Munich, Germany.
Int J Hyg Environ Health. 2016 Jul;219(4-5):380-8. doi: 10.1016/j.ijheh.2016.03.003. Epub 2016 Mar 24.
Persistent organic pollutants are widespread in the environment, and are associated with a particular health and ecological concern. The human body burden of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs/Fs), polybrominated dibenzo-p-dioxins and dibenzofurans (PBDDs/Fs), polychlorinated biphenyls (PCBs), polybrominated diphenylether (PBDEs), and hexabromocyclododecanes (HBCDs) was determined. Blood samples were collected in Germany, originating from 42 randomly selected subjects between 20 and 68 years old. The median (95th percentile) concentrations, expressed as WHO2005-TEQ for PCDD/PCDFs and dioxin-like PCBs, were 6.2 (19.1) pg/g l.w. and 4.1 (8.8) pg/g l.w., respectively. PBDDs/Fs were found with a median of 2.8 pgTEQ/g l.w. and a 95th percentile of 8.7 pgTEQ/g l.w. (using similar interim TEF values as for PCDDs/Fs) On a median basis, the contribution of PCDD/Fs, dioxin-like PCBs, and PBDDs/Fs to total TEQ were 47%, 31%, and 21%, respectively. The sum of the 6 non-dioxin-like PCBs exhibited a median of 267ng/g l.w. and a 95th percentile of 834ng/g l.w. The median value for the sum of six tetra- to hepta-PBDE congeners was 1.7ng/g l.w. (95th percentile: 4.9ng/g l.w.). BDE 209 was the most abundant congener with a median of 1.8ng/g l.w. HBCDs were only found in some samples, and concentrations ranged between the limit of detection (5ng/g l.w.) and the limit of quantification (16ng/g l.w.). Results for PBDEs and HBCDs are comparable to other European studies. Our study demonstrated that the body burden of PCDD/Fs and PCBs declined continously since the last three decades, but exposure may exceed precautionary guideline levels.
持久性有机污染物广泛存在于环境中，与特定的健康和生态问题有关。本研究测定了人体内多氯二苯并对二恶英和呋喃（PCDD/Fs）、多溴二苯并对二恶英和呋喃（PBDD/Fs）、多氯联苯（PCBs）、多溴联苯醚（PBDEs）和六溴环十二烷（HBCDs）的含量。本研究在德国采集了 42 名年龄在 20 至 68 岁之间的随机受试者的血液样本。以世界卫生组织 2005-TEQ 表示的 PCDD/PCDF 和类似二恶英的 PCB 的中位数（95%分位数）浓度分别为 6.2（19.1）pg/g 湿重和 4.1（8.8）pg/g 湿重。用类似 PCDD/Fs 的临时 TEF 值表示，PBDD/Fs 的中位数为 2.8 pgTEQ/g 湿重，95%分位数为 8.7 pgTEQ/g 湿重。以中位数为基础，PCDD/Fs、类似二恶英的 PCB 和 PBDD/Fs 对总 TEQ 的贡献分别为 47%、31%和 21%。6 种非二恶英类 PCBs 的总和中位数为 267ng/g 湿重，95%分位数为 834ng/g 湿重。6 种四氯至七氯 PBDE 同系物总和的中位数为 1.7ng/g 湿重（95%分位数：4.9ng/g 湿重）。BDE-209 是最丰富的同系物，中位数为 1.8ng/g 湿重。HBCDs 仅在一些样本中检出，浓度范围在检测限（5ng/g 湿重）和定量限（16ng/g 湿重）之间。PBDEs 和 HBCDs 的结果与其他欧洲研究相当。本研究表明，自上个世纪 30 年代以来，PCDD/Fs 和 PCBs 的人体负荷持续下降，但接触水平可能超过了预防准则的水平。
