Grippo Angela J, Johnson Alan Kim
Department of Psychology, The University of Iowa, Iowa City 52242-1407, USA.
Neurosci Biobehav Rev. 2002 Dec;26(8):941-62. doi: 10.1016/s0149-7634(03)00003-4.
Psychological depression is shown to be associated with several aspects of coronary artery disease (CAD), including arrhythmias, myocardial infarction, heart failure and sudden death. The physiological mechanisms accounting for this association are unclear. Hypothalamic-pituitary-adrenal dysregulation, diminished heart rate variability, altered blood platelet function and noncompliance with medial treatments have been proposed as mechanisms underlying depression and cardiovascular disease. Recent evidence also suggests that reduced baroreflex sensitivity, impaired immune function, chronic fatigue and the co-morbidity of depression and anxiety may be involved in the relationship between depression and cardiovascular dysregulation. An experimental strategy using animal models for investigating underlying physiological abnormalities in depression is presented. A key to understanding the bidirectional association between depression and heart disease is to determine whether there are common changes in brain systems that are associated with these conditions. Such approaches may hold promise for advancing our understanding of the interaction between this mood disorder and CAD.
心理抑郁与冠状动脉疾病（CAD）的多个方面相关，包括心律失常、心肌梗死、心力衰竭和猝死。导致这种关联的生理机制尚不清楚。下丘脑 - 垂体 - 肾上腺调节异常、心率变异性降低、血小板功能改变以及不遵守药物治疗被认为是抑郁和心血管疾病的潜在机制。最近的证据还表明，压力反射敏感性降低、免疫功能受损、慢性疲劳以及抑郁和焦虑的共病可能与抑郁和心血管调节异常之间的关系有关。本文介绍了一种使用动物模型研究抑郁潜在生理异常的实验策略。理解抑郁与心脏病之间双向关联的关键在于确定与这些病症相关的脑系统是否存在共同变化。此类方法可能有望增进我们对这种情绪障碍与CAD之间相互作用的理解。
