Holt W S, Regan C D, Trempe C
Am J Ophthalmol. 1976 Apr;81(4):403-12. doi: 10.1016/0002-9394(76)90294-4.
Thirteen cases of acute posterior multifocal placoid pigment epitheliopathy occurred in young adults or older children. In ten there was a characteristic, possibly infectious syndrome that preceded the onset of ocular manifestations by a few weeks. One patient developed cerebrospinal fluid lymphocytosis and a cerebral vasculitis coincident with the ocular changes. Extensive evaluations for viral and other infectious etiologies in this and other cases were unrevealing. An inflammatory reaction was observed in the anterior chambers of most patients, and cells were noted in the anterior vitreous bodies of a few patients. In one instance a serous detachment of the retina occurred adjacent to the optic disk. Our findings and others support the conclusion that the fundus lesions resulted from a multifocal choroiditis primarily involving the choriocapillaris and affecting the pigment epithelium and retina secondarily. The data also suggested that the choroiditis may be associated with a more widespread vasculitis occurring as an immune reaction to an earlier systemic infection.
13例急性后极部多灶性鳞状色素上皮病变发生于年轻人或大龄儿童。其中10例在眼部表现出现前几周有特征性的、可能为感染性的综合征。1例患者在眼部病变同时出现脑脊液淋巴细胞增多和脑血管炎。对该病例及其他病例进行的广泛病毒及其他感染病因评估均无结果。多数患者前房可见炎症反应，少数患者前玻璃体可见细胞。1例视盘旁发生视网膜浆液性脱离。我们的发现及其他研究结果支持以下结论：眼底病变由主要累及脉络膜毛细血管、继而影响色素上皮和视网膜的多灶性脉络膜炎引起。数据还提示，脉络膜炎可能与作为对早期全身感染的免疫反应而发生的更广泛的血管炎有关。
