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通过显微镜观察有丝分裂:深入了解活的分裂细胞内部的进展

Mitosis through the microscope: advances in seeing inside live dividing cells.

作者信息

Rieder Conly L, Khodjakov Alexey

机构信息

Lab of Cell Regulation, Division of Molecular Medicine, Wadsworth Center, Albany, NY 12201-0509, USA.

出版信息

Science. 2003 Apr 4;300(5616):91-6. doi: 10.1126/science.1082177.

Abstract

The most visually spectacular events in the life of a cell occur when it divides. This is especially true in higher eukaryotes, where the size and geometry of cells allow the division process to be followed through a microscope with considerable clarity. In these organisms, the membrane surrounding the nucleus breaks down after the replicated DNA has condensed to form discrete chromosomes. Several new structures are then assembled to separate the chromosomes and partition the cytoplasm into two separate cells.

摘要

细胞生命中最具视觉冲击力的事件发生在它分裂的时候。在高等真核生物中尤其如此,在这些生物中,细胞的大小和形态使得通过显微镜能够相当清晰地观察到分裂过程。在这些生物体中,围绕细胞核的膜在复制后的DNA浓缩形成离散的染色体后会解体。然后会组装几个新结构来分离染色体并将细胞质分成两个独立的细胞。

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