Lindner Oliver, Busch Frank, Burchert Wolfgang
Institute of Molecular Biophysics, Radiopharmacy and Nuclear Medicine, Heart and Diabetes Center North Rhine-Westphalia, Bad Oeynhausen, Germany.
Eur J Nucl Med Mol Imaging. 2003 Jun;30(6):819-25. doi: 10.1007/s00259-003-1175-4. Epub 2003 Apr 4.
The preparation of syringes for routine applications in nuclear medicine, and in particular the calibration procedure, is associated with high radiation exposure to the hands. To reduce this radiation burden, our group developed a modified calibration procedure based on a device that we refer to as the ActivoFix, which allows syringes to be drawn up inside the dose calibrator. This study investigated the performance of the new device as compared to the usual procedure of syringe calibration with regard to the absorbed radiation dose to the hands (fingertips and middle finger bases), the precision of the calibration procedure and the time required to calibrate syringes. Fourteen experienced nuclear medicine technologists drew up syringes from an initial eluate of 8.2 GBq using the conventional technique and the new calibration procedure. All technologists had to calibrate syringes with 50 MBq, 250 MBq and 650 MBq. This sequence was repeated four times using the conventional technique and then the new procedure. The equivalent dose to the hands was measured with thermoluminescent dosimeters. The exact amount of radioactivity in the syringe and the time needed for the calibration procedure were also recorded. The reduction in equivalent dose using the new device compared with the routine procedure ranged from 8.3- to 19.6-fold (mean 14.3-fold) for the fingers of the dominant hand and from 13.6- to 40.3-fold (mean 27-fold) for those of the non-dominant hand (total mean 21.3-fold). For small volumes, time could be saved with the ActivoFix, whereas for greater volumes time was lost. The device produced less variability in calibrating doses at 250 MBq and 650 MBq. Following the ALARA principle, the new device can be recommended for syringe calibration in nuclear medicine because the use of the ActivoFix-based procedure reduces finger dose by an average factor of 21, improves the precision of calibration and reduces the filling time for small volumes.
用于核医学常规操作的注射器准备工作，尤其是校准程序，会使手部受到高辐射暴露。为减轻这种辐射负担，我们团队基于一种名为ActivoFix的设备开发了一种改进的校准程序，该设备可使注射器在剂量校准仪内吸取溶液。本研究调查了这种新设备与常规注射器校准程序相比，在手部（指尖和中指基部）吸收的辐射剂量、校准程序的精度以及校准注射器所需时间方面的性能。14名经验丰富的核医学技术人员使用传统技术和新校准程序，从初始洗脱液8.2 GBq中吸取注射器。所有技术人员都必须校准50 MBq、250 MBq和650 MBq的注射器。使用传统技术然后使用新程序重复此序列四次。用热释光剂量计测量手部的当量剂量。还记录了注射器中放射性的准确量以及校准程序所需的时间。与常规程序相比，使用新设备时优势手手指的当量剂量降低了8.3至19.6倍（平均14.3倍），非优势手手指的当量剂量降低了13.至40.3倍（平均27倍）（总体平均21.3倍）。对于小体积，使用ActivoFix可以节省时间，而对于大体积则会浪费时间。该设备在250 MBq和650 MBq剂量校准时产生的变异性较小。遵循尽可能降低辐射剂量（ALARA）原则，新设备可推荐用于核医学中的注射器校准，因为基于ActivoFix的程序使用可使手指剂量平均降低21倍，提高校准精度并减少小体积的填充时间。
