Nakamura W, Nishimoto Y
C R Seances Soc Biol Fil. 1975;169(2):468-72.
The effect of L-5-hydroxytryptophan (L-5-HTP) against the depression of tumor-resisting power in host animal, which is induced by a whole body x-irradiation of 500 R, was studied. Host animal and tumor cell used were LAF, hybrid mouse and mastocytoma cell, respectively. The i.p. injected dose of L-5-HTP was 6.25 mg per mouse, which is most effective for protecting mice from radiation-induced hematopoietic death. In the experimental conditions, the agent was not effective to prevent the radiation-induced depression of tumor-resisting power of the animal.
研究了L-5-羟色氨酸（L-5-HTP）对500伦琴全身X射线照射诱导的宿主动物抗肿瘤能力下降的影响。所用的宿主动物和肿瘤细胞分别是LAF杂种小鼠和肥大细胞瘤细胞。L-5-HTP的腹腔注射剂量为每只小鼠6.25毫克，这对保护小鼠免受辐射诱导的造血死亡最为有效。在实验条件下，该药物对预防辐射诱导的动物抗肿瘤能力下降无效。
