Nakamura W, Komatsu K
C R Seances Soc Biol Fil. 1986;180(1):121-7.
The effect of a transplantation of mastocytoma cells in the abdominal cavity on the sensitivity of mice to a systemic hyperthermia was studied. The systemic hyperthermia was induced by exposing whole-body of animals to 2,450 MHz waves under anesthesia. Core body temperature was raised up to 42.0 +/- 0.2 degrees C in 15 min and maintained constant at the temperature for variable length of time. Thermosensitivity of animal was expressed with LD50, 42 degrees which was the length of heating time at the temperature of 42 degrees C lethal for 50% of the animals examined. The transplants were mastocytoma FMA3 cells. They were transplanted at a dose of 10(5) cells per mouse. The LD50, 42 degrees observed 3, 12 hrs, 1, 2, 3 and 6 days after the transplantation was 33, 23, 17, 24 and 35 min, respectively. In mice without tumor it was 43 min.
研究了腹腔内移植肥大细胞瘤细胞对小鼠全身热疗敏感性的影响。全身热疗是在麻醉状态下将动物全身暴露于2450兆赫的波中诱导产生的。核心体温在15分钟内升至42.0±0.2摄氏度，并在该温度下保持恒定一段可变的时间。动物的热敏感性用LD50,42表示，即42摄氏度下使50%受试动物致死的加热时间长度。移植的是肥大细胞瘤FMA3细胞。以每只小鼠10(5)个细胞的剂量进行移植。移植后3、12小时、1、2、3和6天观察到的LD50,42分别为33、23、17、24和35分钟。无肿瘤小鼠的LD50,42为43分钟。
