Croxton Thomas L, Weinmann Gail G, Senior Robert M, Wise Robert A, Crapo James D, Buist A Sonia
Division of Lung Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA.
Am J Respir Crit Care Med. 2003 Apr 15;167(8):1142-9. doi: 10.1164/rccm.200207-756WS.
Chronic obstructive pulmonary disease (COPD) is a common condition, and one difficult to manage. Available treatments, other than smoking cessation, are only minimally effective, and the knowledge basis for clinical decision making is limited. To identify areas in which further clinical research may lead to significant improvements in the care of patients with COPD, the National Heart, Lung, and Blood Institute convened a Working Group, entitled "Clinical Research in COPD: Needs and Opportunities," on March 21-22, 2002. This group of experts identified important questions in the field and made the following recommendations: (1) establish a multicenter Clinical Research Network to perform multiple, short-term clinical trials of treatments in patients with moderate-to-severe COPD; (2) create a system for the standardized collection, processing, and distribution of lung tissue specimens and associated clinical and laboratory data; (3) develop standards for the classification and staging of COPD; (4) characterize the development and progression of COPD using measures and biomarkers that relate to current concepts of pathogenesis; and (5) evaluate indications for long-term oxygen therapy for patients with COPD.
慢性阻塞性肺疾病（COPD）是一种常见病症，且难以治疗。除戒烟外，现有的治疗方法效果甚微，临床决策的知识基础也很有限。为确定哪些领域的进一步临床研究可能会显著改善慢性阻塞性肺疾病患者的护理，美国国立心肺血液研究所于2002年3月21日至22日召集了一个名为“慢性阻塞性肺疾病的临床研究：需求与机遇”的工作组。该专家小组确定了该领域的重要问题并提出了以下建议：（1）建立一个多中心临床研究网络，对中重度慢性阻塞性肺疾病患者进行多种治疗方法的短期临床试验；（2）创建一个系统，用于标准化收集、处理和分发肺组织标本以及相关的临床和实验室数据；（3）制定慢性阻塞性肺疾病的分类和分期标准；（4）使用与当前发病机制概念相关的指标和生物标志物来描述慢性阻塞性肺疾病的发生和发展；（5）评估慢性阻塞性肺疾病患者长期氧疗的指征。
