Ising Hartmut, Babisch Wolfgang, Kruppa Barbara
Federal Environmental Agency, Institute for Water, Soil and Air Hygiene, Corrensplatz 1, D - 14191 Berlin, Germany.
Noise Health. 1999;1(4):37-48.
Noise has the potential to cause stress reactions. Chronic noise-induced stress accelerates the ageing of the myocardium and thus increase the risk of myocardial infarction. The involved pathomechanisms include acute increase of catecholamines or cortisol under acute noise exposure and an interaction between endocrine reactions and intracellular Ca/Mg shifts. Chronic noise exposure of animals on a diet with suboptimal magnesium content led to increase of connective tissue and calcium, and decrease of magnesium in the myocardium. These changes were correlated to noradrenaline and normal ageing. Post mortem studies of hearts from victims of ischemic heart diseases confirmed the importance of Ca/Mg shifts in humans. Recent epidemiological studies support the importance of noise as a risk factor in circulatory and heart diseases, especially in myocardial infarction.
噪音有可能引发应激反应。长期噪音诱发的应激会加速心肌老化，从而增加心肌梗死的风险。相关的病理机制包括急性噪音暴露下儿茶酚胺或皮质醇的急性增加，以及内分泌反应与细胞内钙/镁转移之间的相互作用。给镁含量未达最佳水平饮食的动物长期暴露于噪音中，会导致心肌中结缔组织和钙增加，镁减少。这些变化与去甲肾上腺素和正常衰老相关。对缺血性心脏病患者心脏的尸检研究证实了钙/镁转移在人类中的重要性。最近的流行病学研究支持了噪音作为循环系统和心脏病，尤其是心肌梗死的危险因素的重要性。
