7,8-二氢-7,8-二羟基苯并(a)芘-9,10-氧化物与DNA的反应与从细胞中分离出的苯并(a)芘-DNA产物的关系。 - Suppr

Suppr

超能文献

The reaction of 7,8-dihydro-7,8-dihydroxybenzo (a) pyrene-9,10-oxide with DNA in relation to the benzo (a) pyrene-DNA products isolated from cells.

作者信息

Osborne M R, Thompson M H, Tarmy E M, Beland F A, Harvey R G, Brookes P

出版信息

Chem Biol Interact. 1976 Jun;13(3-4):343-8. doi: 10.1016/0009-2797(76)90086-7.

DOI:10.1016/0009-2797(76)90086-7

PMID:1269050

Abstract

摘要

相似文献

The reaction of 7,8-dihydro-7,8-dihydroxybenzo (a) pyrene-9,10-oxide with DNA in relation to the benzo (a) pyrene-DNA products isolated from cells.7,8-二氢-7,8-二羟基苯并(a)芘-9,10-氧化物与DNA的反应与从细胞中分离出的苯并(a)芘-DNA产物的关系。

Chem Biol Interact. 1976 Jun;13(3-4):343-8. doi: 10.1016/0009-2797(76)90086-7.

Formation of DNA-binding products from isolated benzo[a]pyrene metabolites in rat liver nuclei.

Chem Biol Interact. 1978 Mar;20(3):311-21. doi: 10.1016/0009-2797(78)90109-6.

Stereoselectivity of benzo[a]pyrene diol epoxides by DNA for adduct formation with N2 on guanine.苯并[a]芘二醇环氧化物与鸟嘌呤上的N2形成DNA加合物的立体选择性。

Prog Clin Biol Res. 1985;172A:187-97.

Fluorescence study of DNA-binding metabolites of benzo(a)pyrene formed in hepatocytes isolated from 3-methylcholanthrene-treated rats.从经3-甲基胆蒽处理的大鼠分离出的肝细胞中形成的苯并(a)芘DNA结合代谢物的荧光研究。

Cancer Res. 1978 Aug;38(8):2600-7.

Only one type of benzo(a) pyrene-DNA adduct is detected in transformable mouse cells.在可转化的小鼠细胞中仅检测到一种苯并(a)芘 - DNA加合物。

Biochem Biophys Res Commun. 1981 Apr 15;99(3):820-9. doi: 10.1016/0006-291x(81)91238-9.

Electrically induced fluorescence as a method for studying benzo[a]pyrene binding to DNA.电诱导荧光法用于研究苯并[a]芘与DNA的结合

FEBS Lett. 1982 Mar 8;139(1):101-4. doi: 10.1016/0014-5793(82)80496-1.

Kinetic analysis of the metabolism of benzo(a)pyrene to phenols, dihydrodiols, and quinones by high-pressure chromatography compared to analysis by aryl hydrocarbon hydroxylase assay, and the effect of enzyme induction.通过高压色谱法对苯并(a)芘代谢为酚类、二氢二醇和醌类的动力学分析与通过芳烃羟化酶测定法的分析比较，以及酶诱导的影响。

Cancer Res. 1975 Dec;35(12):3642-50.

Metabolism of benzo(a)pyrene by isolated hepatocytes and factors affecting covalent binding of benzo(a)pyrene metabolites to DNA in hepatocyte and microsomal systems.苯并(a)芘在分离的肝细胞中的代谢以及影响苯并(a)芘代谢产物在肝细胞和微粒体系统中与DNA共价结合的因素。

Arch Biochem Biophys. 1980 Oct 15;204(2):511-23. doi: 10.1016/0003-9861(80)90063-6.

On the nature of the product which results when 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene is metabolised in vitro and bound to DNA.关于7,8-二氢-7,8-二羟基苯并(a)芘在体外代谢并与DNA结合后所产生产物的性质。

Chem Biol Interact. 1976 Jun;13(3-4):349-52. doi: 10.1016/0009-2797(76)90087-9.

Influence of inducers and inhibitors of mixed-function oxidasts on benzo(a)pyrene binding to the DNA of rat liver nuclei.混合功能氧化酶诱导剂和抑制剂对苯并(a)芘与大鼠肝细胞核DNA结合的影响。

Cancer Res. 1977 May;37(5):1443-9.

引用本文的文献

(+/-)-7alpha,8beta-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)-pyrene is an intermediate in the metabolism and binding to DNA of benzo(a)pyrene.（±）-7α，8β-二羟基-9β，10β-环氧-7,8,9,10-四氢苯并（a）芘是苯并（a）芘代谢及与DNA结合过程中的一种中间体。

Proc Natl Acad Sci U S A. 1976 Aug;73(8):2679-81. doi: 10.1073/pnas.73.8.2679.

Binding of benzo(a)pyrene metabolites to cellular DNA in perfused rat lungs.苯并(a)芘代谢产物与灌注大鼠肺细胞DNA的结合。

Naunyn Schmiedebergs Arch Pharmacol. 1978 Jul;303(3):303-7. doi: 10.1007/BF00498059.

Different tumours induced by benzo(a)pyrene and its 7,8-dihydrodiol injected into adult mouse salivary gland.将苯并(a)芘及其7,8-二氢二醇注射到成年小鼠唾液腺中诱导产生的不同肿瘤。

Br J Cancer. 1978 May;37(5):657-61. doi: 10.1038/bjc.1978.103.

Enzymic control of irreversible binding of metabolically activated benzo(a)pyrene in perfused rat liver by monooxygenase activity.通过单加氧酶活性对灌注大鼠肝脏中代谢活化苯并(a)芘不可逆结合的酶促控制。

Arch Toxicol. 1977 Dec 30;39(1-2):149-58. doi: 10.1007/BF00343282.

Aryl hydrocarbon hydroxylase activity in pulmonary alveolar macrophages and lymphocytes from lung cancer and noncancer patients: a correlation with family histories of cancer.肺癌患者和非癌患者肺泡巨噬细胞及淋巴细胞中的芳烃羟化酶活性：与癌症家族史的相关性

Biochem Genet. 1979 Oct;17(9-10):795-806. doi: 10.1007/BF00504304.

Mechanism of phage phiX174 DNA inactivation by benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide.苯并(a)芘-7,8-二氢二醇-9,10-环氧化物使噬菌体phiX174 DNA失活的机制

Proc Natl Acad Sci U S A. 1977 Aug;74(8):3335-9. doi: 10.1073/pnas.74.8.3335.

A bacteriophage system for screening and study of biologically active polycyclic aromatic hydrocarbons and related compounds.一种用于筛选和研究生物活性多环芳烃及相关化合物的噬菌体系统。

Proc Natl Acad Sci U S A. 1977 Apr;74(4):1378-82. doi: 10.1073/pnas.74.4.1378.

Modification of DNA by the benzo[a]pyrene metabolite diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene.苯并[a]芘代谢物二醇环氧化物r-7,t-8-二羟基-t-9,10-环氧-7,8,9,10-四氢苯并[a]芘对DNA的修饰作用

Proc Natl Acad Sci U S A. 1978 Jan;75(1):415-9. doi: 10.1073/pnas.75.1.415.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验