Giomi Barbara, Pestelli Elisabetta, Massi Daniela, Caproni Marzia, Fabbri Paolo
Department of Dermatology, Università degli Studi di Firenze, Via degli Alfani, 23, 50121, Firenze, Italy.
J Reprod Med. 2003 Mar;48(3):209-12.
Lichen planus (LP) is a common inflammatory dermatosis the diagnosis of which can be very complex when it affects the female genital area exclusively. The condition should be managed by both dermatologists and gynecologists because the association between vulvar LP and other immune-mediated disorders occurs frequently.
Vulvar LP was diagnosed in 37-year-old woman whose past history was significant for ulcerative colitis (UC) since the age of 21. The oral mucosa and skin were completely unaffected, but whitish papules and plaques were seen diffusely on the whole vulvar region, which had become sclerotic and edematous. Microscopic examination of lesional tissue confirmed the diagnosis, showing classic histologic features in spite of the mixed and hypertrophic clinical variant. Oral therapy with cyclosporin at an initial dose of 250 mg/d led to complete remission within 3 months.
This case is reported on for the rarity of isolated vulvar involvement by LP and for the excellent response to treatment.
扁平苔藓(LP)是一种常见的炎症性皮肤病,当它仅累及女性生殖器区域时,其诊断可能非常复杂。由于外阴LP与其他免疫介导的疾病之间经常存在关联,因此该疾病应由皮肤科医生和妇科医生共同管理。
一名37岁女性被诊断为外阴LP,她自21岁起就患有溃疡性结肠炎(UC),病史显著。口腔黏膜和皮肤完全未受影响,但整个外阴区域弥漫性可见白色丘疹和斑块,该区域已变得硬化和水肿。对病变组织的显微镜检查证实了诊断,尽管临床变体为混合性和肥厚性,但仍显示出典型的组织学特征。初始剂量为250mg/d的环孢素口服治疗在3个月内导致完全缓解。
报告该病例是因为LP单独累及外阴罕见,且对治疗反应良好。