Padmanabhan V, Karsch F J, Lee J S
Department of Pediatrics, and the Reproductive Sciences Program, University of Michigan, Ann Arbor, MI 48109, USA.
Reprod Suppl. 2002;59:67-82.
FSH is a key reproductive hormone involved in the control of ovarian folliculogenesis and steroidogenesis. Multiple regulatory mechanisms govern the release of FSH. These regulatory mechanisms appear to work in concert to modulate the level, pattern and biological potency of circulating FSH, thereby adjusting the gonadotrophic stimulus to meet the challenge of a changing physiological need. This review (i) summarizes various neuroendocrine, autocrine and paracrine mechanisms involved in the control of FSH production and secretion; (ii) identifies possible mechanisms by which LH and FSH are differentially released from the same gonadotrophs; (iii) considers the means by which changes in the quality of the FSH signal are regulated and the implication of such changes; and (iv) emphasizes how large animal models have helped to advance our understanding of FSH control.
促卵泡生成素（FSH）是一种关键的生殖激素，参与卵巢卵泡发生和类固醇生成的调控。多种调节机制控制着FSH的释放。这些调节机制似乎协同作用，以调节循环中FSH的水平、模式和生物学效能，从而调整促性腺刺激，以应对不断变化的生理需求带来的挑战。本综述：（i）总结了参与FSH产生和分泌控制的各种神经内分泌、自分泌和旁分泌机制；（ii）确定促黄体生成素（LH）和FSH从同一促性腺激素细胞中差异释放的可能机制；（iii）探讨FSH信号质量变化的调节方式及其影响；（iv）强调大型动物模型如何有助于推进我们对FSH控制的理解。
