犬急性出血性胰腺炎中前列腺素的释放
Prostaglandin release in canine acute haemorrhagic pancreatitis.
作者信息
Glazer G, Bennett A
出版信息
Gut. 1976 Jan;17(1):22-6. doi: 10.1136/gut.17.1.22.
Abstract
Acute haemorrhagic pancreatitis was induced in greyhound dogs by a bile salt/trypsin injection into the main pancreatic duct. Prostaglandin-like activity in the pancreatic venous blood, right atrial blood, and arterial blood was measured by bioassay. Activity rose significantly in the pancreatic venous blood of test dogs but not in controls. Chromatographic analysis of the peritoneal exudate from the dogs with pancreatitis showed high levels of prostaglandin E-like material (mean 43 ng/ml prostaglandin E2 equivalents). It seems likely that prostaglandins contribute to the induced pancreatitis.
摘要
通过向灵缇犬的主胰管注射胆盐/胰蛋白酶诱导急性出血性胰腺炎。通过生物测定法测量胰腺静脉血、右心房血和动脉血中的前列腺素样活性。试验犬的胰腺静脉血中活性显著升高，而对照组则没有。对胰腺炎犬的腹腔渗出液进行色谱分析，结果显示前列腺素E样物质含量很高（平均相当于43 ng/ml前列腺素E2）。前列腺素似乎可能导致了诱发的胰腺炎。
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