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犬急性出血性胰腺炎中前列腺素的释放

Prostaglandin release in canine acute haemorrhagic pancreatitis.

作者信息

Glazer G, Bennett A

出版信息

Gut. 1976 Jan;17(1):22-6. doi: 10.1136/gut.17.1.22.

DOI:10.1136/gut.17.1.22
PMID:1269976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1411043/
Abstract

Acute haemorrhagic pancreatitis was induced in greyhound dogs by a bile salt/trypsin injection into the main pancreatic duct. Prostaglandin-like activity in the pancreatic venous blood, right atrial blood, and arterial blood was measured by bioassay. Activity rose significantly in the pancreatic venous blood of test dogs but not in controls. Chromatographic analysis of the peritoneal exudate from the dogs with pancreatitis showed high levels of prostaglandin E-like material (mean 43 ng/ml prostaglandin E2 equivalents). It seems likely that prostaglandins contribute to the induced pancreatitis.

摘要

通过向灵缇犬的主胰管注射胆盐/胰蛋白酶诱导急性出血性胰腺炎。通过生物测定法测量胰腺静脉血、右心房血和动脉血中的前列腺素样活性。试验犬的胰腺静脉血中活性显著升高，而对照组则没有。对胰腺炎犬的腹腔渗出液进行色谱分析，结果显示前列腺素E样物质含量很高（平均相当于43 ng/ml前列腺素E2）。前列腺素似乎可能导致了诱发的胰腺炎。

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1
Prostaglandin release in canine acute haemorrhagic pancreatitis.犬急性出血性胰腺炎中前列腺素的释放
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2
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Int J Pancreatol. 1989 Jul;5(1):69-75. doi: 10.1007/BF02925699.
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Dig Dis Sci. 1979 Feb;24(2):117-22. doi: 10.1007/BF01324738.

本文引用的文献

1
TRYPSIN RELEASE, KININ PRODUCTION, AND SHOCK; RELATIONSHIP IN EXPERIMENTAL AND HUMAN PANCREATITIS.胰蛋白酶释放、激肽生成与休克；在实验性和人类胰腺炎中的关系
Arch Surg. 1964 Aug;89:322-31. doi: 10.1001/archsurg.1964.01320020086014.
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The role of trypsin and of bile salts in the pathogenesis of acute pancreatitis.胰蛋白酶和胆盐在急性胰腺炎发病机制中的作用。
Surg Forum. 1958;9:533-7.
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Cardiovascular effects of prostaglandin E1.前列腺素E1的心血管效应
J Pharmacol Exp Ther. 1967 Jun;156(3):538-47.
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The site of bradykinin release in acute experimental pancreatitis.急性实验性胰腺炎中缓激肽的释放部位。
Arch Surg. 1969 Jan;98(1):73-6. doi: 10.1001/archsurg.1969.01340070091017.
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Effects of prostaglandin E1 on pancreatic exocrine function.前列腺素E1对胰腺外分泌功能的影响。
Gastroenterology. 1971 Feb;60(2):272-8.
6
The release of biologically active substances from isolated lungs by 5-hydroxytryptamine and tryptamine.5-羟色胺和色胺从离体肺中释放生物活性物质。
Br J Pharmacol. 1970 Nov;40(3):582P-583P.
7
Formation and destruction of plasma kinins during experimental acute hemorrhagic pancreatitis in dogs.犬实验性急性出血性胰腺炎期间血浆激肽的形成与破坏
Scand J Gastroenterol Suppl. 1970;5:1-44.
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Acute pancreatitis and pancreatic blood flow.急性胰腺炎与胰腺血流
Surg Gynecol Obstet. 1969 Aug;129(2):331-40.
9
Extraction of prostaglandins from human blood.从人体血液中提取前列腺素。
Nature. 1971 Oct 1;233(5318):336-7. doi: 10.1038/233336b0.
10
Peritoneal lavage therapy in hemorrhagic pancreatitis.出血性胰腺炎的腹腔灌洗疗法
Surgery. 1973 Jul;74(1):106-15.