垂体催乳激素的研究。猪催乳激素的一级结构。

Studies on pituitary lactogenic hormone. The primary structure of the porcine hormone.

作者信息

Li C H

出版信息

Int J Pept Protein Res. 1976;8(2):205-24. doi: 10.1111/j.1399-3011.1976.tb02497.x.

DOI:10.1111/j.1399-3011.1976.tb02497.x

Abstract

The complete amino acid sequence of porcine lactogenic hormone has been elucidated. It consists of 199 amino acid residues with three disulfide bridges formed by residues 4-11, 58-174, and 191-199. The two tryptophan residues are in positions 91 and 150. A high degree of homology exists between the known structure of ovine prolactin and the porcine lactogenic hormone. This led to a re-examination of residues 82-90 in the ovine prolactin structure, where an extra leucine was found in position 88.

摘要

猪催乳激素的完整氨基酸序列已被阐明。它由199个氨基酸残基组成，有三个二硫键，分别由第4 - 11、58 - 174和191 - 199位的残基形成。两个色氨酸残基分别位于第91和150位。绵羊催乳素的已知结构与猪催乳激素之间存在高度同源性。这导致了对绵羊催乳素结构中第82 - 90位残基的重新审视，在第88位发现了一个额外的亮氨酸。