2-(α-羟基苄基)-苯并咪唑和胍对肠道病毒感染小鼠的成功治疗
Successful treatment of enterovirus-infected mice by 2-(alpha-hydroxybenzyl)-benzimidazole and guanidine.
作者信息
Eggers H J
出版信息
J Exp Med. 1976 Jun 1;143(6):1367-81. doi: 10.1084/jem.143.6.1367.
Abstract
Echo virus 9- or Coxsackie A 9-infected newborn mice are protected from paralysis and death by combined treatment with nontoxic concentrations of HBB plus guanidine. HBB alone also protects Coxsackie A 9, but not echo virus 9-infected animals, whereas guanidine alone is ineffective in either case. Protection is due to inhibition of virus multiplication via the antiviral activity of these selective inhibitors. Treatment must be begun at the latest 48 h after virus inoculation. 3 days of treatment are sufficient if started at the time of virus inoculation. Failure of protection after treatment with one compound alone is not due to rapid development of drug-resistant virus mutants. Infected, successfully treated mice may develop a solid immunity.
摘要
用无毒浓度的人β-珠蛋白（HBB）加胍联合治疗，可使感染埃可病毒9型或柯萨奇A9型病毒的新生小鼠免于瘫痪和死亡。单独使用HBB也可保护感染柯萨奇A9型病毒的小鼠，但对感染埃可病毒9型的动物无效，而单独使用胍在两种情况下均无效。这种保护作用是由于这些选择性抑制剂的抗病毒活性抑制了病毒繁殖。治疗必须在病毒接种后最迟48小时开始。如果在病毒接种时开始治疗，3天的治疗就足够了。单独用一种化合物治疗后保护失败并非由于耐药病毒突变体的快速产生。感染且成功治疗的小鼠可能会产生牢固的免疫力。
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